翻译

个人简介

Dr. Gonzalez Bosc holds a PhD (2000) from the University of Buenos Aires, Argentina. She is the Director of the Biomedical Sciences Graduate Program (BSGP) at UNM, chairs the Institutional animal Care and Use Committee (IACUC), and directs the Cardiovascular and Metabolic Disease Signature Program (CMVD)

专业领域

  • Vascular biology
  • 肺动脉高压
  • 低氧
  • 发炎

成就与奖项

  • Respiration Section New Investigator Award. 2010. American Physiological Society
  • Dalsemer Awar. Biomedical Research Grant. 2007. American Lung Association
  • Minority Travel Award to Experimental Biology. 2007. American Physiological Society/National Institute of Diabetes and Digestive and Kidney Diseases
  • Scientist Development Award. 2005. American Heart Association
  • Research Position. Programa Ramón y Cajal. 2004. Ministerio de Educación y Ciencia. Spain.
  • Affiliate Postdoctoral Fellowship. 2002 and 2004. American Heart Association

主要出版物

  • NFATc3 Regulation of Collagen V Expression Contributes to Cellular Immunity to Collagen Type V and Hypoxic Pulmonary Hypertension. Joshua R. Sheak, David T. Jones, Benjamin J Lantz, Levi D. Maston, Danielle Vigil, Thomas C. Resta, Micaela M. Resta, Tamara A. Howard, Nancy L. Kanagy, Yan Guo, Ewa Jankowska-Gan, Jeremy A. Sullivan, Rudolf K. Braun, William J. Burlingham, and Laura V. Gonzalez Bosc. Am J Physiol Lung Cell Mol Physiol. In-press. 2020
  • Ewa Jankowska-Gan, Vrushali V Agashe, Diego A Lema, Ying Zhou, Laura Gonzalez-Bosc, Jeremy Sullivan, Daniel S Greenspan, William J Burlingham. Donor HLA-DR drives the development of de novo autoimmunity following lung and heart transplantation. Transplantation Direct. In-press. 2020
  • Levi D. Maston, David T. Jones, Wieslawa Giermakowska, Tamara A. Howard, Judy L. Cannon, Wei Wang, Yongyi Wei, Weimin Xuan, Thomas C. Resta, Laura V. Gonzalez Bosc. Central Role of T Helper 17 Cells in Chronic Hypoxia-Induced Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2017. 312(5):L609-L624. PMC5451600
  • Maston LD, Jones DT, Giermakowska W, Resta TC, Ramiro-Diaz J, Howard TA, Jernigan NL, Herbert L, Maurice AA, Gonzalez Bosc LV. Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension. Pulm Circ. 2018 Jul-Sep;8(3):2045894018780734. PMC6055240
https://www.ncbi.nlm.nih.gov/myncbi/laura%20v.gonzalez%20bosc.1/bibliography/public/

性别

女性

语言

  • 英语,西班牙语

调研

 慢性缺氧引起的肺动脉高压

在过去的 12 年中,我们的研究重点是了解慢性缺氧 (CH) 引起的肺动脉高压发展的潜在机制。 我们在这个领域做出了重大贡献。 我的小组是第一个证明钙调节的转录因子、活化 T 细胞同种型 c3 (NFATc3) 的核因子是 CH 诱导的肺动脉重塑和高血压所必需的。 在过去的 6 年中,我们一直在研究炎症在 CH 诱导的肺动脉高压中的作用。 我们已经确定 Th17 细胞在 CH 暴露后定位于肺动脉的血管周围区域,并且这些细胞显着促进了肺动脉高压的发展。 我们最近发现 CH 暴露肺动脉血管周围区域的胶原蛋白 V,作为一种自身抗原,触发 Th17 介导的炎症反应,导致肺动脉高压。 我们的研究由美国心脏协会、NIH 和国防部资助。

课程教授

Medical Curriculum:

  • Phase I. Clinical Reasoning. University of New Mexico Health Science Center. Facilitator. Spring semester. 2016
  • Phase I. Gastrointestinal/Nutrition Block. University of New Mexico Health Science Center. Six students. Tutor (36 contact hours/year). 2015.
  • Phase I. Cardiovascular/Pulmonary/Renal Block. University of New Mexico Health Science Center. Six students. Tutor (36 contact hours/year). 2014.

Graduate School Curriculum:

  • Graduate Physiology (Biomed. Sci. 510). University of New Mexico Health Science Center. Lecturer (8 lecture hours/year). 2005 –
  • Advance Topics in Cellular and Systems Physiology (Biomed. Sci. 657). University of New Mexico Health Science Center. Lecturer (15 contact hours/year). 2005, 2007, 2011, 2013, 2017, 2020.

研究与奖学金

认证:

  • Instructor with pedagogic formation in university teaching. Orientation: health sciences. 1998. School of Pharmacy and Biochemistry. University of Buenos Aires.  阿根廷布宜诺斯艾利斯