翻译

个人简介

Dr. Brigman received his B.A. in Psychology from Loyola University Maryland and went on to complete his Ph.D. in Cognitive Neuroscience from George Washington University.  His postdoctoral fellowship was in the Laboratory of Genomic and Behavioral Neuroscience in the NIAAA Intramural Program where he twice won the Fellows Award for Research Excellence. He established his research program in Department of Neurosciences at the University of New Mexico School of Medicine in 2011. He received a Regents’ Lectureship in 2016 for excellence in research, teaching and service and was promoted to Associate Professor with Tenure in 2017.

专业领域

行为神经科学
Executive Control
发展障碍
Translational measures of brain activity

教育培训

PhD, Cognitive Neuroscience:
乔治华盛顿大学
华盛顿特区

BA, Psycology:
洛约拉大学
马里兰州巴尔的摩市

成就与奖项

  • Fellow, International Behavioral Neuroscience Society - 2018
  • Regents Lectureship, University of New Mexico HSC – 2016
  • Co-Founder and Faculty Organizer, New Mexico Brain Bee - 2015
  • Fellows Award for Research Excellence, National Institutes of Health – 2011 & 2008

主要出版物

  • Marquardt, K., Cavanagh, J.F. & Brigman, J.L. (2020)。 子宫内的酒精暴露会破坏行为灵活性所需的皮质-纹状体协调。 Neuropharmacology.162 正在进行 PMCID。 
  • Olguin, S.L., Thompson, S.M., Young, J.W. and Brigman, J.L. (在新闻).  Moderate prenatal alcohol exposure impairs cognitive control, but not attention, on a rodent touchscreen continuous performance task.  基因、大脑和行为。
  • Marquardt, K., Josey, M., Kenton, J.A., Cavanagh, J.F., Holmes, A. & Brigman, J.L. (2019). Impaired cognitive flexibility following NMDAR-GluN2B deletion is associated with altered orbitofrontal-striatal function. 神经. 404年: 338-382 PMC6455963
  • Kenton, J.A., Castillo, R., Holmes A. & Brigman, J.L. (2018) Cortico-hippocampal GluN2B is essential for efficient visual-spatial discrimination learning in a touchscreen paradigm. 学习和记忆的神经生物学。 156:60-67 PMC6300131
  • Marquardt, K., Sigdel, R. & Brigman, J.L. (2017) Value encoding and signal propogation in the orbitofrontal cortex during touch-screen reversal learning. Neurobiology of Learning and Memory. 139 179-188. PMC5372695

性别

他,他

语言

  • 英语

调研

The focus of research in the Brigman Lab is to further our understanding of the maladaptive behavioral changes that accompany alcohol exposure, drug addiction and numerous neuropsychiatric disorders.  Current theories have proposed that early or repeated alcohol exposure can lead to progressive loss of cortically-mediated executive control. As top-top down control is lost, habitual patterns dominate the behavioral repertoire leading to decreased quality of life.  If this maladaptive shift in behavior could be prevented or reversed, it would provide an important therapeutic tool. Our research focuses on developing models that allow us to investigate the role of both genetic factors and molecular mechanisms in mediating executive control behaviors.  One potential mechanism of interest due to its established role in the neuro-plasticity underlying learning and memory is the glutamatergic N-methyl-D-aspartate receptor (NMDAR).  The Brigman Lab explores how NMDAR subunit composition and receptor expression is altered both by learning, and exposure.  Another major focus of the lab is understanding the optimal organization of neuronal firing in neural circuits in vivo, and how alterations in NMDAR may disrupt these patterns, leading to loss of executive control and poorer functional outcome.

课程教授

  • Principles of Neurobiology (BIOM509) - 课程总监
  • Neurophysiology & Neuroanatomy (BIOM533) - 讲师
  • Neurobiology of Alcoholism (BIOM505) - 讲师
  • Statistical Methods (BIOM505) - 讲师 
  • Neuroanatomy Laboratory - 课程总监
  • Brain Stem Anatomy - 讲师
  • Functional Cortical Anatomy - 讲师
  • Limbic System & ARAS - 讲师
  • Mechanisms of Learning and Conditioning - 讲师