翻译

专业领域

神经生理学
心脏电生理学
成像
行程
TBI

教育培训

博士(1991):
墨尔本大学
Australia, Victoria, Melbourne

BS (Hons), (1987):
Filders University
Australia, South Australia, Adelaide

学士 (1986):
Adelade University
Australia, South Australia, Adelaide

成就与奖项

  • Faculty Teaching Excellence Award - 2002, 2010, 2014, 2019
  • Erwin W. Lewis Teaching Award, UNM SOM - 2016, 2017, 2018
  • Team Science Award, UNM Health Sciences Center - 2016
  • Khatali Teaching Award, UNM SOM - 2004, 2006, 2008, 2010
  • William G. Dail Endowed Professorship for Excellence in Teaching - 2011-2014
  • A. Earl Walker Award for Neuroscience Research at UNM - 2010
  • Dean’s Award of Distinction, UNM SOM - 2003
  • Smith Klein & French Neuroscience Prize, Flinders University of South Australia - 1988

主要出版物

  • C.W. Shuttleworth, R.D. Andrew, Y. Akbari, C. Ayata, et al., Which Spreading Depolarizations are Deleterious to Brain Tissue?  Neurocritical Care 32 (2020) 317-322. https://pubmed.ncbi.nlm.nih.gov/31388871/
  • A.P. Carlson, M. Abbas, R.L. Alunday, F. Qeadan, C.W. Shuttleworth.  Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial.  J Neurosurgery.  130 (2019) 1513-1519. https://pubmed.ncbi.nlm.nih.gov/29799344/
  • K.M. Reinhart & C.W. Shuttleworth.  Ketamine reduces deleterious consequences of spreading depolarizations.  Experimental Neurology 305 (2018) 121-128. https://pubmed.ncbi.nlm.nih.gov/29653188/
  • J.A. Hartings, C.W. Shuttleworth, S.A. Kirov, C. Ayata, et al., The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy.  J Cereb Blood Flow Metab.  37 (2017) 1571-1594 https://pubmed.ncbi.nlm.nih.gov/27328690/
  • B.E. Lindquist & C.W. Shuttleworth.  Evidence that adenosine contributes to Leao’s spreading depression in vivo.  J Cereb Blood Flow Metab.  37 (2017) 1656-1669 https://pubmed.ncbi.nlm.nih.gov/27217381/
  • I. Aiba & C.W. Shuttleworth.  Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons.  J. Physiol. 590 (2012) 5877-5893. https://pubmed.ncbi.nlm.nih.gov/22907056/

性别

他,他

语言

  • 英语

调研

Our laboratory is currently focused almost entirely on spreading depolarization (SD) events, which are profound depolarizations of neurons and glia that propagate slowly throughout the brain. A colloquial term for these events is "Brain Tsunamis" (点击此处详细了解。 to see a short introductory video about brain tsunamis).  There has been a resurgence in interest in SD, as recent clinical recordings have implicated SDs as key contributors to progression of acute brain injuries (including stroke and traumatic brain injury).   The long-term goal of our lab is to help develop SD interventions that can be applied at late time points, and which ultimately will be translatable to the clinic. We use brain slices and animal models to identify 1) fundamental mechanisms that underlie damaging effects of SD, 2) approaches to support compromised tissues to recover from repeated SD episodes and 3) potential beneficial effects of SD that might be important for functional recovery of injured brain.  Our lab collaborates closely with clinical colleagues in the departments of Neurosurgery, Psychiatry and Neurology to explore roles of SD in a range of disorders, and potential treatments targeting SD.

课程教授

本科医学教育:

  • Neurosciences Block
  • GI and Nutrition Block

生物医学研究生课程:

  • Neurophysiology (Biomed 531)
  • Functional Neuroanatomy (Biomed 533)